Plasma drug testing for D and L isomers of amphetamine and methamphetamine by liquid chromatography mass spectrometry with a range of 2.5 to 1000 ng/ml

Carpenter, R.E., Long, M., Robbins, B.
Publication date
September 2022
International Society for Laboratory Hematology Conference
Bologna, Italy
Existing in two enantiomeric forms, D- or L-methamphetamine, produce radically different effects on the human nervous system. The D- form can be used therapeutically as a treatment for overeating disorders, narcolepsy, and Attention Deficit Disorder. But it also produces habit-forming central nervous system effects engendering potential illegal abuse. There is a need to develop a plasma matrix assay for determining the enantiomeric form of methamphetamine D- and L- isomers.
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